Klinik und Poliklinik für Frauenheilkunde
 Universitätsmedizin Leipzig



The Special AT-rich Sequence Binding Protein 1 (SATB1) and its role in solid tumors.

Frömberg A, Engeland K, Aigner A

Cancer Lett. 2018 Jan 3. pii: S0304-3835(18)30004-1.


Cell cycle arrest through indirect transcriptional repression by p53: I have a DREAM.

Engeland K.
Cell Death Differ. 2018 Jan;25(1):114-132. 


Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes.

Fischer M, Müller GA.

Crit Rev Biochem Mol Biol. 2017 Dec;52(6):638-662. 

The DREAM complex through its subunit Lin37 cooperates with Rb to initiate quiescence.
Mages CF, Wintsche A, Bernhart SH, Müller GA.
Elife. 2017 Sep 18;6. pii: e26876.

Human papilloma virus E7 oncoprotein abrogates the p53-p21-DREAM pathway.

Fischer M, Uxa S, Stanko C, Magin TM, Engeland K.

Sci Rep. 2017 Jun 1;7(1):2603.


Census and evaluation of p53 target genes. 

Fischer M

Oncogene. 2017 Jul 13;36(28):3943-3956.




Timing of transcription during the cell cycle: Protein complexes binding to E2F, E2F/CLE, CDE/CHR, or CHR promoter elements define early and late cell cycle gene expression.
Müller GA, Stangner K, Schmitt T, Wintsche A, Engeland K.
Oncotarget. 2016 Jul 28. doi: 10.18632/oncotarget.10888.

Fischer M, Grossmann P, Padi M, DeCaprio JA.
Nucleic Acids Res. 2016 Jul 27; 44(13): 6070–6086.             


Probing receptor-ligand interactions on a single molecule level using optical tweezers.

Stangner, T., C. Wagner, C. Gutsche, K. Stangner, D. Singer, S. Angioletti-Uberti and F. Kremer; H. Ohshima (Eds.) Encyclopedia of Biocolloid and Biointerface Science. John Wiley & Sons, New Jersey, ISBN: 978-1-118-54276-7, 2016, pp 915-932    

Cell Cycle 2016 June.

The p53-p21-DREAM-CDE/CHR pathway regulates G2/M cell cycle genes.
Fischer M, Quaas M, Steiner L, Engeland K.
Nucleic Acids Res. 2016 Jan 8;44(1):164-74


Indirect p53-dependent transcriptional repression of Survivin, CDC25C, and PLK1 genes requires the cyclin-dependent kinase inhibitor p21/CDKN1A and CDE/CHR promoter sites binding the DREAM complex.
Fischer M, Quaas M, Nickel A, Engeland K.
Oncotarget. 2015 Dec 8;6(39):41402-17.

Does Arabidopsis thaliana DREAM of cell cycle control?
Fischer M, DeCaprio JA
EMBO J. 2015 Aug 4; 34(15): 1987–1989.

Simplify p53: just an activator.
Engeland K.
Oncotarget. 2015 Jan 1;6(1):3-4.

Cyclin F suppresses B-Myb activity to promote cell cycle checkpoint control.
Klein DK, Hoffmann S, Ahlskog JK, O'Hanlon K, Quaas M, Larsen BD, Rolland B, Rösner HI, Walter D, Kousholt AN, Menzel T, Lees M, Johansen JV, Rappsilber J, Engeland K, Sørensen CS.
Nat Commun. 2015 Jan 5;6:5800.



The transcription factor p53: not a repressor, solely an activator. 
Fischer M, Steiner L, Engeland K.
Cell Cycle. 2014;13(19):3037-58.

The CHR site: definition and genome-wide identification of a cell cycle transcriptional element. 
Müller GA, Wintsche A, Stangner K, Prohaska SJ, Stadler PF, Engeland K.
Nucleic Acids Res. 2014;42(16):10331-50

Proteome analysis of the HIV-1 Gag interactome. 
Engeland CE, Brown NP, Börner K, Schümann M, Krause E, Kaderali L, Müller GA, Kräusslich HG.
Virology. 2014 Jul;460-461:194-206.

Cell cycle, oncogenic and tumor suppressor pathways regulate numerous long and macro non-protein-coding RNAs. 
Hackermüller J, Reiche K, Otto C, Hösler N, Blumert C, Brocke-Heidrich K, Böhlig L, Nitsche A, Kasack K, Ahnert P, Krupp W, Engeland K, Stadler PF, Horn F.
Genome Biol. 2014 Mar 4;15(3):R48.

Polo-like kinase 4 transcription is activated via CRE and NRF1 elements, repressed by DREAM through CDE/CHR sites and deregulated by HPV E7 protein. 
Fischer M, Quaas M, Wintsche A, Müller GA, Engeland K.
Nucleic Acids Res. 2014 Jan;42(1):163-80.



The forkhead transcription factor FOXM1 controls cell cycle-dependent gene expression through an atypical chromatin binding mechanism. 
Chen X, Müller GA, Quaas M, Fischer M, Han N, Stutchbury B, Sharrocks AD, Engeland K.
Mol Cell Biol. 2013 Jan;33(2):227-36.

p53 and cell cycle dependent transcription of kinesin family member 23 (KIF23) is controlled via a CHR promoter element bound by DREAM and MMB complexes. 
Fischer M, Grundke I, Sohr S, Quaas M, Hoffmann S, Knörck A, Gumhold C, Rother K.
PLoS One. 2013 May 1;8(5):e63187.



p53 can repress transcription of cell cycle genes through a p21(WAF1/CIP1)-dependent switch from MMB to DREAM protein complex binding at CHR promoter elements. 
Quaas M, Müller GA, Engeland K.
Cell Cycle. 2012 Dec 15;11(24):4661-72.

The CHR promoter element controls cell cycle-dependent gene transcription and binds the DREAM and MMB complexes. 
Müller GA, Quaas M, Schümann M, Krause E, Padi M, Fischer M, Litovchick L, DeCaprio JA, Engeland K.
Nucleic Acids Res. 2012 Feb;40(4):1561-78.

Allele-specific siRNA knockdown as a personalized treatment strategy for vascular Ehlers-Danlos syndrome in human fibroblasts. 
Müller GA, Hansen U, Xu Z, Griswold B, Talan MI, McDonnell NB, Briest W.
FASEB J. 2012 Feb;26(2):668-77.

Human ESC/iPSC-based "Omics" and Bioinformatics for Translational Research. 
Müller G, Tarasov KV, Gundry RL, Boheler KR.
Drug Discov Today Dis Models. 2012;9(4):e161-e170.



The tumor suppressor p53 induces expression of the pregnancy-supporting human chorionic gonadotropin (hCG) CGB7 gene. 
Sohr S, Engeland K.
Cell Cycle. 2011 Nov 1;10(21):3758-67.

p53 signature and serous tubal in-situ carcinoma in cases of primary tubal and peritoneal carcinomas and serous borderline tumors of the ovary. 
Leonhardt K, Einenkel J, Sohr S, Engeland K, Horn LC.
Int J Gynecol Pathol. 2011 Sep;30(5):417-24.

The cellular protein lyric interacts with HIV-1 Gag. 
Engeland CE, Oberwinkler H, Schümann M, Krause E, Müller GA, Kräusslich HG.
J Virol. 2011 Dec;85(24):13322-32.

 One function--multiple mechanisms: the manifold activities of p53 as a transcriptional repressor. 
Böhlig L, Rother K.
J Biomed Biotechnol. 2011;2011:464916.

p53 activates the PANK1/miRNA-107 gene leading to downregulation of CDK6 and p130 cell cycle proteins. 
Böhlig L, Friedrich M, Engeland K.
Nucleic Acids Res. 2011 Jan;39(2):440-53.



The haploinsufficient Col3a1 mouse as a model for vascular Ehlers-Danlos syndrome. 
Cooper TK, Zhong Q, Krawczyk M, Tae HJ, Müller GA, Schubert R, Myers LA, Dietz HC, Talan MI, Briest W.
Vet Pathol. 2010 Nov;47(6):1028-39.

The retinal dehydrogenase/reductase retSDR1/DHRS3 gene is activated by p53 and p63 but not by mutants derived from tumors or EEC/ADULT malformation syndromes. 
Kirschner RD, Rother K, Müller GA, Engeland K.
Cell Cycle. 2010 Jun 1;9(11):2177-88.

The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription. 
Müller GA, Engeland K.
FEBS J. 2010 Feb;277(4):877-93.



Human chorionic gonadotropin attracts regulatory T cells into the fetal-maternal interface during early human pregnancy. 
Schumacher A, Brachwitz N, Sohr S, Engeland K, Langwisch S, Dolaptchieva M, Alexander T, Taran A, Malfertheiner SF, Costa SD, Zimmermann G, Nitschke C, Volk HD, Alexander H, Gunzer M, Zenclussen AC.
J Immunol. 2009 May 1;182(9):5488-97.



RHAMM is differentially expressed in the cell cycle and downregulated by the tumor suppressor p53. 
Sohr S, Engeland K.
Cell Cycle. 2008 Nov 1;7(21):3448-60.

Identification of two regulatory binding sites which confer myotube specific expression of the mono-ADP-ribosyltransferase ART1 gene. 
Friedrich M, Böhlig L, Kirschner RD, Engeland K, Hauschildt S.
BMC Mol Biol. 2008 Oct 21;9:91.

Trastuzumab therapy vs tetracycline controlled ERBB2 downregulation: influence on tumour development in an ERBB2-dependent mouse tumour model. 
Hermes M, Schormann W, Brulport M, Uhlemann K, Lupatsch F, Horn LC, Schumann A, Allgaier C, Weishaupt M, Engeland K, Müller GA, Mössner J, Bauer A, Schiffer IB, Gebhard S, Schmidt M, Lausch E, Prawitt D, Wilhelm C, Hengstler JG.
Br J Cancer. 2008 May 6;98(9):1525-32.

The CCN3 gene coding for an extracellular adhesion-related protein is transcriptionally activated by the p53 tumor suppressor. 
Böhlig L, Metzger R, Rother K, Till H, Engeland K.
Cell Cycle. 2008 May 1;7(9):1254-61.

Transcriptional activation of the tumor suppressor and differentiation gene S100A2 by a novel p63-binding site. 
Kirschner RD, Sänger K, Müller GA, Engeland K.
Nucleic Acids Res. 2008 May;36(9):2969-80.

The CCN3 gene coding for an extracellular adhesion-related protein is transcriptionally activated by the p53 tumor suppressor. 
Böhlig L, Metzger R, Rother K, Till H, Engeland K.
Cell Cycle. 2008 May 1;7(9):1254-61.

C-Kit receptor (CD117) in the porcine urinary tract. 
Metzger R, Neugebauer A, Rolle U, Böhlig L, Till H.
Pediatr Surg Int. 2008 Jan;24(1):67-76.



Cell cycle-dependent transcription of cyclin B2 is influenced by DNA methylation but is independent of methylation in the CDE and CHR elements. 
Tschöp K, Engeland K.
FEBS J. 2007 Oct;274(20):5235-49.

Expression of cyclin-dependent kinase subunit 1 (Cks1) is regulated during the cell cycle by a CDE/CHR tandem element and is downregulated by p53 but not by p63 or p73. 
Rother K, Li YY, Tschöp K, Kirschner R, Müller GA, Mössner J, Engeland K.
Cell Cycle. 2007 Apr 1;6(7):853-62.

Gene expression of cyclin-dependent kinase subunit Cks2 is repressed by the tumor suppressor p53 but not by the related proteins p63 or p73. 
Rother K, Dengl M, Lorenz J, Tschöp K, Kirschner R, Mössner J, Engeland K.
FEBS Lett. 2007 Mar 20;581(6):1166-72.

Chimpanzee, orangutan, mouse, and human cell cycle promoters exempt CCAAT boxes and CHR elements from interspecies differences. 
Müller GA, Heissig F, Engeland K.
Mol Biol Evol. 2007 Mar;24(3):814-26

p53 downregulates expression of the G1/S cell cycle phosphatase Cdc25A. 
Rother K, Kirschner R, Sänger K, Böhlig L, Mössner J, Engeland K.
Oncogene. 2007 Mar 22;26(13):1949-53.



Genomic organization and expression of the human mono-ADP-ribosyltransferase ART3 gene. 
Friedrich M, Grahnert A, Klein C, Tschöp K, Engeland K, Hauschildt S.
Biochim Biophys Acta. 2006 Jun;1759(6):270-80.

Human cyclin B3. mRNA expression during the cell cycle and identification of three novel nonclassical nuclear localization signals. 
Tschöp K, Müller GA, Grosche J, Engeland K.
FEBS J. 2006 Apr;273(8):1681-95.



The p53-family members p63 and p73 inhibit insulin-like growth factor-I receptor gene expression in colon cancer cells. 
Nahor I, Abramovitch S, Engeland K, Werner H.
Growth Horm IGF Res. 2005 Dec;15(6):388-96.

Analysis of mono-ADP-ribosyltransferase 4 gene expression in human monocytes: splicing pattern and potential regulatory elements. 
Grahnert A, Friedrich M, Engeland K, Hauschildt S.
Biochim Biophys Acta. 2005 Sep 25;1730(3):173-86.

TAp63gamma can substitute for p53 in inducing expression of the maspin tumor suppressor. 
Spiesbach K, Tannapfel A, Mössner J, Engeland K.
Int J Cancer. 2005 Apr 20;114(4):555-62.



SIRF--a novel regulator element controlling transcription from the p55Cdc/Fizzy promoter during the cell cycle. 
Haugwitz U, Tschöp K, Engeland K.
Biochem Biophys Res Commun. 2004 Jul 30;320(3):951-60.

Identification of Tcf-4 as a transcriptional target of p53 signalling. 
Rother K, Johne C, Spiesbach K, Haugwitz U, Tschöp K, Wasner M, Klein-Hitpass L, Möröy T, Mössner J, Engeland K.
Oncogene. 2004 Apr 22;23(19):3376-84.



Three CCAAT-boxes and a single cell cycle genes homology region (CHR) are the major regulating sites for transcription from the human cyclin B2 promoter. 
Wasner M, Haugwitz U, Reinhard W, Tschöp K, Spiesbach K, Lorenz J, Mössner J, Engeland K.
Gene. 2003 Jul 17;312:225-37.

Cyclin B1 transcription is enhanced by the p300 coactivator and regulated during the cell cycle by a CHR-dependent repression mechanism. 
Wasner M, Tschöp K, Spiesbach K, Haugwitz U, Johne C, Mössner J, Mantovani R, Engeland K.
FEBS Lett. 2003 Feb 11;536(1-3):66-70.

Interactions between p300 and multiple NF-Y trimers govern cyclin B2 promoter function. 
Salsi V, Caretti G, Wasner M, Reinhard W, Haugwitz U, Engeland K, Mantovani R.
J Biol Chem. 2003 Feb 28;278(9):6642-50. Epub 2002 Dec 12.



Differential regulation of transcription and induction of programmed cell death by human p53-family members p63 and p73. 
Dietz S, Rother K, Bamberger C, Schmale H, Mössner J, Engeland K.
FEBS Lett. 2002 Aug 14;525(1-3):93-9.

A single cell cycle genes homology region (CHR) controls cell cycle-dependent transcription of the cdc25C phosphatase gene and is able to cooperate with E2F or Sp1/3 sites. 
Haugwitz U, Wasner M, Wiedmann M, Spiesbach K, Rother K, Mössner J, Engeland K.
Nucleic Acids Res. 2002 May 1;30(9):1967-76.



Regulation and possible function of beta-catenin in human monocytes. 
Thiele A, Wasner M, Müller C, Engeland K, Hauschildt S.
J Immunol. 2001 Dec 15;167(12):6786-93.

Expression of the p53 homologues p63 and p73 in multiple simultaneous gastric cancer. 
Tannapfel A, Schmelzer S, Benicke M, Klimpfinger M, Kohlhaw K, Mössner J, Engeland K, Wittekind C.
J Pathol. 2001 Sep;195(2):163-70.

Expression of the cell cycle phosphatase cdc25C is down-regulated by the tumor suppressor protein p53 but not by p73. 
Krause K, Haugwitz U, Wasner M, Wiedmann M, Mössner J, Engeland K.
Biochem Biophys Res Commun. 2001 Jun 15;284(3):743-50.

Role of prostaglandins in regulation of pancreatic enzyme secretion by various diets. 
Holler B, Ogami Y, Zabel-Langhennig A, Tillack D, Engeland K, Keim V, Mössner J.
Dig Dis Sci. 2001 Feb;46(2):289-95.

NF-Y mediates the transcriptional inhibition of the cyclin B1, cyclin B2, and cdc25C promoters upon induced G2 arrest. 
Manni I, Mazzaro G, Gurtner A, Mantovani R, Haugwitz U, Krause K, Engeland K, Sacchi A, Soddu S, Piaggio G.
J Biol Chem. 2001 Feb 23;276(8):5570-6. Epub 2000 Nov 28.



The tumour suppressor protein p53 can repress transcription of cyclin B. 
Krause K, Wasner M, Reinhard W, Haugwitz U, Dohna CL, Mössner J, Engeland K.
Nucleic Acids Res. 2000 Nov 15;28(22):4410-8.

A CDE/CHR tandem element regulates cell cycle-dependent repression of cyclin B2 transcription. 
Lange-zu Dohna C, Brandeis M, Berr F, Mössner J, Engeland K.
FEBS Lett. 2000 Nov 3;484(2):77-81.

Decreased expression of p27 protein is associated with advanced tumor stage in hepatocellular carcinoma. 
Tannapfel A, Grund D, Katalinic A, Uhlmann D, Köckerling F, Haugwitz U, Wasner M, Hauss J, Engeland K, Wittekind C.
Int J Cancer. 2000 Jul 20;89(4):350-5.



Cyclooxygenase-2 transcription is stimulated and amylase secretion is inhibited in pancreatic acinar cells after induction of acute pancreatitis. 
Zabel-Langhennig A, Holler B, Engeland K, Mössner J.
Biochem Biophys Res Commun. 1999 Nov 19;265(2):545-9.

Expression of p73 and its relation to histopathology and prognosis in hepatocellular carcinoma. 
Tannapfel A, Wasner M, Krause K, Geissler F, Katalinic A, Hauss J, Mössner J, Engeland K, Wittekind C.
J Natl Cancer Inst. 1999 Jul 7;91(13):1154-8.

Expression of p73, a novel protein related to the p53 tumour suppressor p53, and apoptosis in cholangiocellular carcinoma of the liver.
 Tannapfel A, Engeland K, Weinans L, Katalinic A, Hauss J, Mössner J, Wittekind C.
Br J Cancer. 1999 Jun;80(7):1069-74.

The cyclin B2 promoter depends on NF-Y, a trimer whose CCAAT-binding activity is cell-cycle regulated. 
Bolognese F, Wasner M, Dohna CL, Gurtner A, Ronchi A, Muller H, Manni I, Mossner J, Piaggio G, Mantovani R, Engeland K.
Oncogene. 1999 Mar 11;18(10):1845-53.



A new model of cell cycle-regulated transcription: repression of the cyclin A promoter by CDF-1 and anti-repression by E2F. 
Liu N, Lucibello FC, Engeland K, Müller R.
Oncogene. 1998 Jun 11;16(23):2957-63.



Cell cycle-regulated repression of B-myb transcription: cooperation of an E2F site with a contiguous corepressor element.
 Liu N, Lucibello FC, Zwicker J, Engeland K, Müller R.
Nucleic Acids Res. 1996 Aug 1;24(15):2905-10.

Cell cycle regulation of E2F site occupation in vivo. 
Zwicker J, Liu N, Engeland K, Lucibello FC, Müller R.
Science. 1996 Mar 15;271(5255):1595-7.



Multiple proteins interact with the nuclear inhibitory protein repressor element in the human interleukin-3 promoter. 
Engeland K, Andrews NC, Mathey-Prevot B.
J Biol Chem. 1995 Oct 13;270(41):24572-9.

Cell cycle regulation of cdc25C transcription is mediated by the periodic repression of the glutamine-rich activators NF-Y and Sp1. 
Zwicker J, Gross C, Lucibello FC, Truss M, Ehlert F, Engeland K, Müller R.
Nucleic Acids Res. 1995 Oct 11;23(19):3822-30.

Cell cycle regulation of the cyclin A, cdc25C and cdc2 genes is based on a common mechanism of transcriptional repression. 
Zwicker J, Lucibello FC, Wolfraim LA, Gross C, Truss M, Engeland K, Müller R.
EMBO J. 1995 Sep 15;14(18):4514-22.



Evidence for domain structures of the trifunctional protein and the tetrafunctional protein acting in glyoxysomal fatty acid beta-oxidation.
 Gühnemann-Schäfer K, Engeland K, Linder D, Kindl H.
Eur J Biochem. 1994 Dec 15;226(3):909-15.



Extrahepatic, differential expression of four classes of human alcohol dehydrogenase. 
Engeland K, Maret W.
Biochem Biophys Res Commun. 1993 May 28;193(1):47-53.

Role of arginine 115 in fatty acid activation and formaldehyde dehydrogenase activity of human class III alcohol dehydrogenase. 
Holmquist B, Moulis JM, Engeland K, Vallee BL.
Biochemistry. 1993 May 18;32(19):5139-44.

Mutation of Arg-115 of human class III alcohol dehydrogenase: a binding site required for formaldehyde dehydrogenase activity and fatty acid activation. 
Engeland K, Höög JO, Holmquist B, Estonius M, Jörnvall H, Vallee BL.
Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2491-4.



Evidence for a peroxisomal fatty acid beta-oxidation involving D-3-hydroxyacyl-CoAs. Characterization of two forms of hydro-lyase that convert D-(-)-3-hydroxyacyl-CoA into 2-trans-enoyl-CoA. 
Engeland K, Kindl H.
Eur J Biochem. 1991 Aug 15;200(1):171-8.

Purification and characterization of a plant peroxisomal delta 2, delta 3-enoyl-CoA isomerase acting on 3-cis-enoyl-CoA and 3-trans-enoyl-CoA. 
Engeland K, Kindl H.
Eur J Biochem. 1991 Mar 28;196(3):699-705.



The glyoxysomal beta-oxidation system in cucumber seedlings: identification of enzymes required for the degradation of unsaturated fatty acids. 
Behrends W, Thieringer R, Engeland K, Kunau WH, Kindl H.
Arch Biochem Biophys. 1988 May 15;263(1):170-7.

Characterization of two forms of the multifunctional protein acting in fatty acid beta-oxidation. 
Behrends W, Engeland K, Kindl H.
Arch Biochem Biophys. 1988 May 15;263(1):161-9.


Letzte Änderung: 09.01.2018, 12:46 Uhr
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Klinik und Poliklinik für Frauenheilkunde